Growth of In Situ Hybridization Market – Industry Overview, Size and Share 2017-2024
Category: #reports  By Digvijay Chakravarty  Date: 2019-01-18
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Growth of In Situ Hybridization Market – Industry Overview, Size and Share 2017-2024

In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acids strand (i.e., probe) to localize a specific DNA or RNA sequence in a portion or section of tissue (in situ), or, if the tissue is small enough (e.g., plant seeds, Drosophila embryos), in the entire tissue (whole mount ISH), in cells, and in circulating tumor cells (CTCs).

In situ hybridization (ISH) is a powerful technique for localizing specific nucleic acid targets within fixed tissues and cells, allowing users to obtain temporal and spatial information about gene expression and genetic loci.  While the basic workflow of ISH is similar to that of blot hybridizations the nucleic acid probe is synthesized, labeled, purified, and annealed with the specific target the difference is the greater amount of information gained by visualizing the results within the tissue.

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The global market for In Situ Hybridization (ISH) at $4.3 billion in 2017 is anticipated to reach $7.8 billion by 2024 2017.  CAGR of 7.8% in the next five years (2017 to 2024). Increasing diagnosis and growing incidence & prevalence of cancer, technology advancements in therapeutics, increasing government initiatives globally are expected to drive the growth of the market in the coming years. 

Advances in RNA in situ hybridization transform molecular detection with morphological context enabling new applications.  Scientists use RNA ISH to extract data dimensions.

Companies Profiled: Market Leaders

Leica Biosystems Nussloch GmbH

Thermo Fisher Scientific

F. Hoffmann-La Roche AG

Abbott Laboratories

Agilent Technologies


Qiagen / Exiqon A/S

Merck KGaA

BioGenex Laboratories

BioTechne / Advanced Cell Diagnostics (ACD)

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Key Topics Covered - In Situ Hybridization

Molecular Diagnostics

Cervical Cancer Stain

Fish Steps Reduction

Fluorescence In Situ Hybridization (FISH)

In Situ Hybridization (ISH)

FISH Probe Kit


Chromosonal Abnormalities

Infectious Diseases

Inflammatory Diseases

Fluorescence In Situ Hybridization (FISH)

Chromogenic In Situ Hybridization (CISH)

Human Genetic Tests

Microbial Tests

In Vitro Diagnostics

System for the Analysis of Solid Tumors

Hybridization Technique

Detection of Long Non-

Coding DNA

Coding RNA

Immunohistochemistry (IHC) and RNA in situ Hybridization are widely used technologies sharing the unique capacity to analyze a marker at the single cell level while preserving the morphological context.  In different situations, IHC and ISH are used in conjunction to validate data or provide complementary information.

Table of Contents

1. United States In Situ Hybridization ISH Market Definition and Market Dynamics 16

1.1 US In situ Hybridization Market Overview 16

1.1.1 Antibody Challenges and Validation 16

1.2 Scope of In situ Hybridization in Inflammation 17

1.2.1 RNAscope? Applications 17

2. In-Situ Hybridization Market Shares and Market Forecasts 20

2.1 In-Situ Hybridization Market Driving Forces 20

2.1.1 Identification of Cytokines and their Cellular Origins 21

2.1.2 Detection of Long Non-Coding RNA (lncRNA) in Inflammatory Diseases 21

2.1.3 Role of Inflammatory Pathways During Carcinogenesis 22

2.1.4 Therapeutic Potential Of Secreted Proteins In Inflammatory Diseases 22

2.1.5 Dual ISH-IHC Detect Cytokines During Inflammatory Responses 22

2.2 In Situ Hybridization Market Shares 24

2.2.1 Roche 25

2.2.2 Abbott Molecular 25

2.2.3 Advanced Cell Diagnostics 25

2.2.4 PerkinElmer In Situ Hybridization Market Driving Forces 26

2.2.5 In Situ Hybridization Market Shares, Unit Shipments and Kit Shipments 27

2.3 In Situ Hybridization Market Forecasts 29

2.3.5 In Situ Hybridization Market Segments, Units and Kits, Dollars and Percent, US, 29

2.4 In situ Hybridization Market Segments 31

2.4.1 In Situ Hybridization Market Shares, Dollars, Worldwide, 2012 to 2017 32

2.4.2 Fluorescence (FISH) and Chromogenic (CISH) Detection 33

2.4.3 ISH Applications 36

2.4.4 Multiplex Fluorescence In Situ Hybridization (FISH) 36

2.4.5 Fluorescence In Situ Hybridization (FISH) 37

2.4.6 Cancer Drug Market 40

2.4.7 Chronic Lymphocytic Leukemia (CLL) 40

2.4.8 In-Situ Hybridization Cancer Diagnosis, Cytology, Infectious Disease Molecular Diagnostic 42

2.1.6 In Situ Hybridization Market Segments, Diagnostic Laboratories, Academic & Research Institutes, Contract Research Organizations, and Pharmaceutical & Biotechnology Companies 47

2.5 In-Situ Hybridization Pricing 54

2.5.1 miRCURY LNA miRNA Detection Probes 54

2.5.2 Price and Availability 58

2.6 In-Situ Hybridization Geographical Analysis 61

3 In-Situ Hybridization Research and Technology 68

3.1 Hybridization Technique 68

4 In-Situ Hybridization Company Profiles 69

4.1 Abbott Laboratories 69

4.1.1 Abbott Laboratories Market Categorization 69

4.1.2 In Situ Hybridization Product Category, Application and Specification 70

4.1.3 Abbott Laboratories Vysis Chronic Lymphocytic Leukemia (CLL) FISH Probe Kit (IVD) 71

4.1.12 Abbott Laboratories Molecular Diagnostics 84

4.1.13 Abbott Diagnostic Products 85

4.2 Acupath Laboratories 87

4.2.1 Acupath Laboratories Barrett?s Esophagus FISH 88

4.3 Agilent Technologies 88

4.3.1 Agilent CGH & CGH+SNP Microarrays 91

4.3.2 Agilent Technologies Revenue 91

4.3.3 Agilent Diagnostics and Genomics 93

4.4 Bio-Techne / ACD 96

5 Summary and Conclusions 172

5.1 Analyze A Marker At The Single Cell Level 172

5.2 Advances in RNA In Situ Hybridization 172

6 Appendix A: List Of Nucleic Acid-Based Tests 173

6.1 List: Nucleic Acid-Based Tests Approved by US Center for Devices and Radiological Health 173

6.1.1 List of Human Genetic Tests 174

6.1.2 List of Microbial Tests 191

6.2 In Vitro Diagnostics 233

WinterGreen Research, 235

WinterGreen Research Methodology 236

WinterGreen Research Process 237

Market Research Study 238

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Digvijay Chakravarty

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Digvijay Chakravarty

Digvijay has been into online marketing of market research and other industries for more than 1.3 years. Focusing his efforts across platforms like blogs, news websites, social media and more, he aims to grow fast in his field with the major objective of sharing infor...

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