Neurocrine, Voyager reveal VY-AADC’s Phase I results at AAN 2019
Category: #health  By Saif Ali Bepari  Date: 2019-05-06
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Neurocrine, Voyager reveal VY-AADC’s Phase I results at AAN 2019

Neurocrine Biosciences Inc., along with Voyager Therapeutics Inc., has reportedly announced the Phase 1 results from the VY-AADC trial in eight patients suffering from Parkinson’s disease. Apparently, the patients participated in the open-label trial to test the evaluation of safety & efficacy of VY-AADC and further assess the posterior (from the back of head) surgical delivery approach.

Sources closely related to the development affirmed that treatment with VY-AADC improved the ON time in patients with Parkinson’s disease, without troublesome dyskinesia, by about 1.7 hours from baseline and also lowered the OFF time by around 2.2 hours at twelve months from the baseline. Sources added that exploratory analyses in four of the eight patients having low or no dyskinesia/ absence of ICD (impulse control disorder) at baseline showed better improvement in motor function – inclusive of a 3.2-hour improvement in good ON time from the baseline to 12 months.

Eiry Roberts, M.D., the Chief Medical Officer of Neurocrine Biosciences, was reported saying that the Phase 1 trial results in patients suffering from Parkinson’s provide evidence that administering VY-AADC allows the brain’s neurons to convert levodopa into dopamine and further augment motor function. Roberts added that the results also confirm previous data from a different, ongoing Phase 1 study showing increased coverage of the putamen with VY-AADC leading to rise in AADC enzyme activity, in addition to improvements in motor function & quality of life in Parkinson’s patients, who are in lesser need for any oral levodopa medication.

Parkinson’s disease, for the record, is a chronic, debilitating & progressive neurogenerative disorder which is known for affecting nearly one million people in the United States. Reports reveal that the VY-AADC infusions were well tolerated by patients, undergoing no SAEs (serious adverse events). Reportedly, the Phase 1 results demonstrate the posterior trajectory to be an additional surgical delivery route in the patients.

Source Credits: https://www.globenewswire.com/news-release/2019/05/05/1817140/0/en/Neurocrine-Biosciences-and-Voyager-Therapeutics-Announce-Phase-I-Results-for-VY-AADC-in-Patients-with-Parkinson-s-Disease-at-the-American-Academy-of-Neurology-Annual-Meeting.html

http://phoenix.corporate-ir.net/phoenix.zhtml?c=68817&p=irol-newsArticle&ID=2397126



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Saif Ali Bepari

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Saif Ali Bepari

Saif Ali Bepari currently works a content writer for Market Size Forecasters, Algosonline, and numerous other platforms. A Computer Science graduate who has a zest for writing over coding, he has previously dabbled into technical and creative writing. He now pens down...

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