UCSF scientists make stem cells that are invisible to immune system
Category: #health  By Pankaj Singh  Date: 2019-02-20
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UCSF scientists make stem cells that are invisible to immune system
  • The feat is being touted as a breakthrough in biological engineering that prevented rejection of stem cell transplants in lab studies
     
  • The new study was published in the journal Nature Biotechnology on February 18

Researchers at the UC San Francisco have reportedly utilized the CRISPR-Cas9 gene-editing system to develop the first-ever pluripotent stem cells that are virtually invisible to the immune system. As per trusted sources, the new study was published in the journal Nature Biotechnology on February 18.

The Julien I.E. Hoffman, MD, lead author of the new study and also the Endowed Chair in Cardiac Surgery at UCSF, Tobias Deuse was reportedly quoted saying that the researchers often talk about the therapeutic ability of pluripotent stem cells which can evolve into any adult tissue. However, the immune system has been a prominent hindrance to effective and safe stem cell therapies, Deuse further added.

According to a news release by UC San Francisco, the feat is being touted as a breakthrough in biological engineering that prevented rejection of stem cell transplants in lab studies. It also implies that the regenerative medicine is moving closer to the reality as these stem cells can be developed more efficiently than stem cells that are customized for each patient, cite reliable sources.

The study's senior author and director of the UCSF Transplant and Stem Cell Immunobiology (TSI) Lab, Professor Sonja Schrepfer, MD, Ph.D. reportedly commented that healthcare providers can administer drugs which suppress immune activity and make rejection less likely. However, these drugs unfortunately leave patients more susceptible to cancer and other infections, Schrepfer further added.

For the record, the immune system is programmed to eliminate anything that it perceives as alien to protect the body against infectious invaders which can disrupt the functioning of organs if given free rein. However, it also means that transplanted cells, tissues, or organs are viewed by immune system as potential foreign invaders and subsequently elicits a strong immune response leading to rejection of the transplant.



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Pankaj Singh

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Pankaj Singh

Pankaj Singh Develops content for Market Size Forecasters, Algosonline, and a couple of other platforms. A Post Graduate in Management by qualification, he worked as an underwriter in the UK insurance domain before deciding to switch his field of profession. With exp...

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